COMPARATIVE EVALUATION OF ALTERNATE EMERGENCY FIXATIVES

Fixation is the cornerstone of histopathology.In order to preserve morphology tissue for further details its essential that all components are preserved in a life like state. Formalin universal fixative but on account carcinogenic potential needs be replaced by alternate fixatives which easily available.This study aims assess and compare efficacy alternative local anesthetic solution, normal saline , distilled water buoy hand sanitizer using H & E stained sections. Total sample size 100 sections was obtained from 10 paraffin embedded blocks Indian goat tongue each fixed LA solution ,Normal Saline, Distilled water, Hand 12 hour 24 named as group A B respectively. The were evaluated five parameters then subjected statistical analysis.Kruskal wallis test, Mann –Whitney U test Kappa Statistic used .Significant difference noted four fixatives( < 0.05).On basis results Local Anesthetic found an emergency fixative.